FDA grants orphan drug status to AstraZeneca cancer drug
The FDA has granted orphan drug designation for AstraZeneca's Zactima, which
is designed for the treatment of patients with different forms of thyroid
cancer.
The drug has received the designation as it has potential to treat a disorder
that affects less than 200,000 people in the US. The status confers several
benefits including seven years of market exclusivity in the US upon approval
of the drug.
The drug is designed to be a multitargeted compound, directed to the inhibition
of key cell-signaling pathways involved in tumor growth and spread. Zactima
is being developed to tackle follicular, medullary, anaplastic, locally advanced
and metastatic papillary thyroid cancer.
Tumor cells are targeted through inhibition of epidermal growth factor receptor
(EGFR) and RET tyrosine kinases, while tumor blood supply is targeted through
inhibition of vascular endothelial growth factor receptor (VEGFR) tyrosine
kinase. RET tyrosine kinase activity is an important growth driver in certain
thyroid tumors.
Zactima is currently in phase II clinical trials in medullary thyroid cancer
as well as phase III clinical trials in advanced non-small-cell lung cancer.
Cancer Statistics
Breast Cancer Statistics How Breast Cancer Survival Rates Increased
50%
Breast cancer statistics show that over 1.2 million persons will be diagnosed
with breast cancer worldwide this year, according to the World Health
Organization. For breast cancer and prevention, it has long been known that
regular physical activity has been shown to decrease the likelihood of having
breast cancer. What has not been known or studied has been the effect of
regular physical activity on the breast cancer survival rates or likelihood
of death in women that already have breast cancer. That is, until now.
The breast cancer statistics and findings as reported by the American Medical
Associations Journal of the American Medical Association (JAMA)
in May 2005 were astounding! Certain participants in the study of women with
Stage I, II or III breast cancer achieved a 50% reduction in the death rate
from breast cancer.
Here are these breast cancer statistics: the journal reported that in the
study 2,987 female registered nurses had been diagnosed with breast cancer
during the years 1984-1998. What the study found was that the women who had
physical activity equivalent to walking at a steady pace of 2.0-2.9 miles
per hour for 3-5 hours a week had a death rate of only 50% of the death rate
of women who had physical activity equivalent to walking less than one hour
a week. The conclusion of the breast cancer statistics in the study was that
physical activity after breast cancer has been diagnosed may reduce the risk
of death from breast cancer. The study found that there was little evidence
of any relation between increased physical activity and increased benefit.
Its time to dust off those walking shoes!
As a physical activity, walking can be done almost anytime by anyone anywhere.
All thats needed is a good pair of walking shoes. Walking is fun and
reduces stress. As for injuries, walking has the lowest injury rate of all
the various kinds of exercise.
You can walk with a partner, friend, family member or dog, maybe even a
neighbor's dog. Or you can walk with your favorite headset and music. If
you are walking outdoors with a headset, keep one ear open to hear the sounds
around you.
As for basic walking tips:
· As you begin regular walking, take it easy. Standard advice is to
check with your physician before starting any exercise program. If its
been years or decades since you walked regularly, perhaps you can begin with
5 minutes of walking and slowly increase your time and distance.
· Walking at a pace of 7595 steps a minute will have you walking
at a speed of about 2-3 miles per hour.
· Walk with your head up, looking out in front of you. Do not walk looking
down right in front of you except to navigate any obstacles.
· Really take it easy the first 5 minutes of walking to warm up. Afterwards,
gently stretch for 510 minutes while your muscles are warm.
· Practice good walking form. Your arms should swing naturally in the
direction youre walking, not from side to side across your body. Your
foot should strike the ground on your heel, then a rolling motion forward
toward the ball of your foot, then pushing off with your toes.
And here are some basic walking shoes tips:
· Buy your walking shoes from a sporting shoes store with large selections.
That will give you plenty of choices. And buy your walking shoes later in
the day when your feet will be larger.
· Buy cushioned, supportive walking shoes. To see if a shoe is supportive,
do this test -- take a shoe and turn it upside down. Holding each end of
the shoe, try to fold it. If you find the shoe bends in the middle, then
that shoe is not a supportive shoe. A supportive shoe should bend where your
foot normally bends, near your toes.
· You should allow the width of your index finger between the end of
your shoe and the end of your longest toe, or about one-half inch.
· Buy two pairs of walking shoes, one for home and one for the car or
workplace. And if one pair gets wet, you can use the other pair that day.
Walking is the closest thing to the perfect exercise. In todays fast-paced
society, regular walking can be a welcomed break from the stress of the day.
Maybe youll get to know your neighborhood or neighbors better. There
may be walking trails youve never seen but wanted to.
Wherever and however you choose to walk, not only can the experience be fun,
youll know youre being good to your body in a variety of ways.
Besides the incredible breast cancer statistics and findings of the breast
cancer study, walking helps with weight control and bone strength, elevates
mood, helps build and maintain healthy muscles, joints and heart. With so
many great health benefits, why not get started walking today!
Copyright 2005 InfoSearch Publishing
Olinda Rola is President of InfoSearch Publishing and webmaster of
http://www.safemenopausesolutions.com
- a website of natural solutions for a variety of health problems. For
information about preventing breast cancer, visit
Breast
Cancer and Prevention to read more.
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