PARIS (AP) - Experiments on mice have shown promise for the future of
nanotechnology in treating cancer.
The research brings doctors one step closer to being able to inject patients
with nanoparticles that bore inside tumours and release powerful doses of
cancer-killing drugs while leaving the rest of the body unscathed.
After seeing how the mice were cured of human prostate cancer with the
technology, cancer specialists gathered at the European Cancer Conference
in Paris on Tuesday praised the work as impressive and said they had high
hopes for its application to patients.
Men with prostate cancer who take supplemental lycopene in addition to surgical
removal of the testicles may experience less active disease, less bone pain,
and live longer than those who only have surgical removal of the testicles,
according to a new study in British Journal of Urology International
(2003;92:3758). This is exciting news for millions of men who have
to undergo aggressive treatment for advanced prostate cancer.
Prostate cancer is the most common cancer found in men over the age of 50
years, with more than 200,000 new cases each year in the United States. The
cause of prostate cancer, like many other cancers, is unknown; however, some
studies suggest alterations in testosterone metabolism may play a role in
its development. Prostate cancer is generally slow growing and may not cause
any symptoms until late in the disease. Symptoms may include frequent or
painful urination, dribbling after urination, sensation of incomplete emptying
of the bladder, or blood in the urine. The symptoms of prostate cancer are
similar to those of a non-cancerous condition called benign prostatic hyperplasia
(BPH), so men experiencing these symptoms should consult their physician
for an accurate diagnosis.
In the new study, 54 men with advanced prostate cancer were randomly assigned
to have surgical removal of the testicles (orchidectomy) alone or orchidectomy
plus oral supplementation with 4 mg of lycopene a day. Measurements of PSA
(a blood marker of prostate cancer activity), bone scans, and urinary flow
were taken initially and every three months for two years. Men receiving
lycopene started on the day of their surgery.
After six months, PSA had significantly decreased in both groups, indicating
a reduction in prostate cancer activity. However, PSA levels in those receiving
lycopene were more than 65% lower than in those who did not receive lycopene.
After two years, PSA levels in the lycopene treatment group had fallen into
the normal range, while those who only underwent surgery still had PSA levels
more than twice the upper limit of normal. Urinary symptoms significantly
improved in both groups, but better improvement was again observed in the
lycopene group. The lycopene group also experienced less bone pain.
The survival rates after two years in the lycopene-plus-surgery group and
surgery-only groups were 87% and 78%, respectively, a statistically significant
difference. No adverse side effects were observed in men taking
lycopene.LycopeneLycopene is one of a group of compounds called
carotenoids. It is found in high amounts in tomatoes.
The findings of this study corroborate the findings of other similar studies
examining the effectiveness of lycopene in the treatment of prostate cancer.
However, the amount used in the current study (4 mg per day) was substantially
less than the amounts used in other studies (30 mg per day). It may also
help stimulate the immune system and has been shown to cause cancer cells
to die on their own. Although more research is needed to clarify what amount
of lycopene is most effective, men with prostate cancer may benefit from
taking daily lycopene supplements. Eating one moderately sized tomato a day
also provides approximately 4 mg of lycopene. Other tomato products, such
as an 8-ounce portion of tomato juice or tomato paste may provide up to 25
mg of lycopene.
Darin Ingels, ND, MT (ASCP), received his bachelors degree from Purdue
University and his Doctorate of Naturopathic Medicine from Bastyr University
in Kenmore, WA. Dr. Ingels is the author of The Natural Pharmacist: Lowering
Cholesterol (Prima, 1999) and Natural Treatments for High Cholesterol (Prima,
2000). He currently is in private practice at New England Family Health
Associates located in Southport, CT, where he specializes in environmental
medicine and allergies. Dr. Ingels is a regular contributor to
Vitamin Herb
University.
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