PHILADELPHIA , Oct. 28 /PRNewswire-FirstCall/ -- GlaxoSmithKline (NYSE: GSK)
today announced that the U.S. Food and Drug Administration (FDA) has approved
ARRANON(R) (nelarabine) Injection, a chemotherapy agent, for the treatment
of patients with T-cell acute lymphoblastic leukemia (T-ALL) and T-cell
lymphoblastic lymphoma (T-LBL) whose disease has not responded to or has
relapsed following treatment with at least two chemotherapy regimens. This
use is based on the induction of complete responses. Randomized trials
demonstrating increased survival or other clinical benefit have not been
conducted.
Approximately 1,600 adults and children are diagnosed with T-ALL or T-LBL
in the U.S. each year. A subset of these patients will relapse or develop
disease that is refractory to treatment. There is no standard of treatment
for these patients and their prognosis is particularly poor. To facilitate
the development of ARRANON for this relatively small group of patients, GSK
worked closely with the National Cancer Institute (NCI) of the National
Institutes of Health (NIH), the Children's Oncology Group (COG) and the Cancer
and Leukemia Group B (CALGB), in conjunction with the Southwest Oncology
Group (SWOG).
Do you remember the Smart Bomb footage of the Gulf Wars on CNN, where the
bomb was launched and you watched on full video as the smart munitions flew
thru someones window and exploded? Well, some really brilliant folks
at MIT had an idea. A cancer drug which could go to a cancer cell and penetrate
it like a sponge and then seal-a-meal itself in the cancerous region. Then
go off and attack the cancerous region without hurting nearby cells. Wow.
How did they do it? Using nano-articles, thats how.
The lethal dose of anti-cancer toxins goes off like the Mother of All Bombs
and does not hurt the non-cancerous cells. It has been tested on Melanoma
and Lewis Lung Cancer in rats so far. Soon clinical trials and tests will
begin on real people, but everyone is very excited and pretty certain this
will work very well. It was a group effort at MIT, between nano tech,
bio-medicine and cancer researchers. They are confident that it will be better
for the patient than the chemotherapy due to the reduction of toxicity to
the healthy surrounding tissue cells.
By using this new research and methodology the MIT team hopes to cur off
enemy supply lines, while dropping smart anti-cancer drugs on the cancer
cells. Similar to starving out enemy insurgents and then attacking them from
the air with precision smart bombs, a strategy which is currently ripping
the heart out of our enemy. The nano cell or super Navy Seal like team, is
like a balloon within a localized grid of the modern net-centric battlespace.
A balloon within a balloon, where it releases the treatment, an anti-angiogenic
drug; thus the blood vessels feeding the tumor then collapse, which means
the loaded nanoparticles are trapped in the tumor, and release the chemotherapy.
It worked in the mice, now it is time to use this to attack cancerous areas
in humans. Eighty percent of the mice survived over 65 days; the best so
far would have been only 30 days. The untreated mice died at less than 20
days. The nanocell treatment worked best on melanoma than lung cancer, but
with a little work the researchers believe they will have an answer for safer
treatment for many types of cancers and drastically increase the odds of
survival. The future where cancer is conquered is rapidly approaching, that
is good news for the World and it means more Lance Armstrong types amongst
us. Think on this, because it is all good and it will be here soon.
"Lance Winslow" - If you have innovative thoughts and unique perspectives,
come think with Lance;
www.WorldThinkTank.net/wttbbs
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